How epilepsy knowledge is built
Science & Discovery explains how researchers and specialist teams learn what routine tests can miss, how new technology changes understanding, and why epilepsy knowledge continues to evolve.
This section is not History and it is not lived experience. These pieces focus on research methods, diagnostic limits, emerging evidence and the scientific process behind modern epilepsy care.
Explore Science & Discovery
When the Scalp EEG Sees the Spread, Not the Start
Why deep seizure onset can be difficult to localise from the scalp, and how stereo-EEG changed what specialists can see.
The Lesion MRI Couldn’t See
How MRI-negative epilepsy can still have a structural basis, and how newer imaging and post-processing can reveal subtle abnormalities.
Advanced diagnostic tools
The diagnostic library now includes dedicated pages for several specialist techniques used when routine assessment does not answer the clinical question.
- 7-Tesla MRI in Epilepsy
- EEG Source Imaging
- FDG-PET in Epilepsy
- Functional MRI for Language and Motor Mapping
- Ictal and Interictal SPECT in Epilepsy
- MEG and Magnetic Source Imaging
Evidence standard
More researched science deep dives
- The Discovery of GABA and Why It Changed Epilepsy Science
- Sodium Channels: From Phenytoin to Genetic Epilepsy
- T-Type Calcium Channels and the Biology of Absence Seizures
- From Epileptic Focus to Epileptic Network
- How SUDEP Became Recognised as a Distinct Epilepsy Risk
- SEEG Network Analysis: Looking Beyond the First Electrode Contact
- Functional Connectivity and Connectomics in Epilepsy Surgery
- Diffusion MRI Tractography in Epilepsy Surgery
- High-Frequency Oscillations: An Emerging Biomarker of Epileptogenic Tissue
- Multimodal Data Integration in MRI-Negative Epilepsy Surgery
Science & Discovery pieces are based on peer-reviewed studies, systematic reviews, professional guidance and specialist literature. Where evidence is uncertain or developing, the uncertainty is stated rather than presented as settled fact.
Deep Dives · Understanding Epilepsy · Epilepsy Through History · Voices & Stories